Cats junior forward Anthony Lamb powered his team to a fourth straight win this season, and a fourth straight in the all-time series against the Crimson.
Lamb dropped a career-high 37 points in the 71-65 victory, and scored 18 consecutive points for UVM in the win.
The total is the most for a Vermont player since Taylor Coppenrath put up 37 in the 2005 America East Championship game against Northeastern.
Senior Ernie Duncan was the only other Catamount in double figures, contributing with 14 in the contest.
Vermont Academy grad Corey Johnson led Harvard in scoring with 17 points and five three-pointers.
UVM returns from finals week to battle Northeastern on Sunday, December 16 in Patrick Gym.